Certain glutamine analogs irreversibly inactivate enzymes that bind glutamine. Identify the nucleotide biosynthetic intermediates (and the enzymes that catalyze the reactions that utilize them) that accumulate in the presence of those compounds. For a given pathway, list your answers in the order of the reactions involved.

Answers

Answer 1

Answer:

5-phosphoribosyl-1-pyrophosphate to accumulate, PRPP will accumulate due to the inactivation of the enzyme glutamine-PRPP amidotransferase

Formylglycinamide ribonucleotide (FGAR) will accumulate due to inactivation of the enzyme formylglycinamide ribonucleotide amino transferase.

Xanthylate (XMP) will accumulates because of the inactivation of the GMP synthetase reaction.

Uridine 5'triphosphate (UTP), a nucleotide biosynthetic product as well as an intermediatein the synthesis ofCytidine 5'triphosphate will accumulate due to the inactivation of cytidylate synthetase.

Explanation:

The biosynthesis of nucleotides occurs by means of two pathways: the de novo pathways and the salvage pathways.

The de novo pathways of the synthesis of nucleotides begins with their metabolic precursors which include amino acids, ribose-5-phosphate, carbon (iv) oxide and ammonia.

The salvage pathways reuse the free bases and nucleotides from the breakdown of nucleic acids.

Glutamine analogs that irreversibly inactivate enzymes that bind glutamine will cause accumulation of intermediates in the nucleotide biosynthetic pathways.

Glutamine is used as the amino group donor in the first committed step of de novo synthesis of purine nucleotides. In this step, 5-phosphoribosyl-1-pyrophosphate, (PRPP) is converted to 5-phosphoribosylamine using the amino group of glutamine by the enzyme glutamine-PRPP amidotransferase. Inactivation of this enzyme will cause 5-phosphoribosyl-1-pyrophosphate to accumulate.

In the fourth step of the de novo synthesis of purine nucleotides, inactivation of the enzyme formylglycinamide ribonucleotide amino transferase will cause formylglycinamide ribonucleotide (FGAR) to accumulate.

In the biosynthesis of guanylate from Inosinate, the intermediate xanthylate (XMP) will accumulate due to inactivation of the enzyme xanthylate-glutamine amidotransferase.

In the de novo synthesis of pyrimidine nucleotides, Uridine 5'triphosphate (UTP), a nucleotide biosynthetic oroduct as well as an intermediate of Cytidine 5'triphosphate will accumulate due to the inactivation of cytidylate synthetase.

Carbamoyl phosphate is synthesized by the enzyme carbamoyl phosphate synthetase II using glutamine and bicarbonate and two ATP molecules. However, the other substrates of this enzyme do not accumulate.


Related Questions

Two objects are described below.
Thing 1: It has a mass measured by a pan balance.
Thing 2: It takes the shape of a container.
Which statement is true?
O Both objects are matter.
O Both objects are non-matter.
O The first object is matter, and the second object is non-matter.
The first object is non-matter, and the second object is matter.

Answers

Mass is measured by balance and weight is measured by balance.

Is mass measured by Pan balance?

Two pans are located on either side of a lever in the pan balancing scale. To achieve balance and determine the weight of the other thing, weights are placed on one side of the object and on the other side. Typically, the mass is expressed in grammes or kilogrammes.

Because of its practicality and accuracy, comparative weighing is frequently used to compare two things' masses rather than their absolute values. When preparing reagents and stock solutions, a top pan balance is typically used for rough weighing because minor weight differences do not significantly affect the outcome of analysis.

Two pans are integrated into this particular laboratory scale on either side of a lever. It has two separate applications. 

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When Thing 1: It has a mass measured by a pan balance. Thing 2: It takes the shape of a container. Then Both objects are matter statement is true.

What is Matter?

Any substance with mass and which has volume is considered matter because it occupies space.

Properties of matter:Any characteristics that can be measured, such as an object's density, color, mass, volume, length, malleability, melting point, hardness, odor, temperature, and others, are considered to be part of its properties.Mass:A body's mass is an inherent quality. earlier before  the discovery of the atom and particle physics, it was widely considered to be tied to the amount of matter in a physical body.

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period when cell is not engaged in division

Answers

Interphase is the period of cell cycle in which the cell is not engaged in any kind of cell division. This phase is marked as the preparatory phase for the actual cell division.

What is Cell cycle?

The cell cycle is a series of steps during which the chromosomes and other cellular material double to make two copies of the genetic material. The cell then undergoes division to form two daughter cells, each of the daughter cell receiving one copy of the doubled chromosomal material. The cell cycle is complete when each of the daughter cell is surrounded by its own outer membrane.

   

The interphase is the period when the cell is in a non-dividing state of the cell and this phase can be in different stages: the first gap (G1) between the last mitosis (M) and the S-phase (phase of DNA synthesis) and the second gap (G2) phase between the completion of the S-phase and the next mitosis (M).

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¿Cuál célula es capaz de sobrevivir en
condiciones extremas? *

A) Eubacterias
B) Procariotas
D) Eucariotas
E) Arqueobacterias​

Answers

Answer:

E.) Arqueobacterias​

Explanation:

13. (a) Define area and state its SI units? ​

Answers

Answer:

Area is defined as the magnitude of product of length into breadth.

S. I unit is in m2

Explanation:

A= L x B

What is described: Blood type AB

pls help me i need to finish this biology test tonight

Answers

Answer:

The AB blood type is one that, according to the blood type classification, does not have Anti-A or Anti-B antigens in its cells, with which, in short, it is constituted as the only blood type that is a universal receptor in case you need a transfusion, since you can receive blood from people with blood type 0, A, B or the same AB.

60 POINTS!!!!!
What would happen if a new predator were introduced to prey with which it has not coevolved?

Answers

Answer:

If a new predator were introduced to prey with which it has not coevolved, it could have a devastating effect on the prey species. The prey species may not have adapted behaviors or physical characteristics to protect themselves from the new predator, making them easy targets for predation. This could lead to a decrease in the prey population and an increase in the predator population, ultimately resulting in the destruction of the prey species. Additionally, the introduction of a new predator could disrupt the balance of the existing food web, which could have a ripple effect on other species in the ecosystem.

Explanation:

Answer: leading cause of extinction is the introduction of predators into an isolated system like an island or a lake

i need help plz i’ll give you brainilest

Answers

the answer is Available habitats
The answer is all of those

how do i scientifically defend the theory of evolution

Answers

Answer:

wait wdym defend? like you're in an argument about the theory of evolution and you want to defend your point........?

Cell wall hut not cell
,
Robert Hooke discovered
Organelles.​

Answers

Answer:

Explanation:

WHAT IS YOUR QUESTION ??

Robert hooke discovered cell wall but not the cell organelle because the cell organelle is much smaller in size as compared to the cell wall. Explanation: The microscope which was used by the scientist Robert hooke was a simple microscope

The length of a DNA double helix increases by 0.34 nm (nanometres) for every pair of nucleotides. The total number of nucleotides in a human body cell is
[tex]1.2 \times {10}^{10} [/tex]

Calculate the total length of a double helix in a human body cell (answer to be given in meters)

Pls give me a quick answer​

Answers

(0.34 x 10^-9)(1.2 x 10^10) =4.08m

what is codon, and what does it represent in protein synthesis?​

Answers

Answer:

A codon is a sequence of three DNA or RNA nucleotides that corresponds with a specific amino acid or stop signal during protein synthesis. Each codon corresponds to a single amino acid (or stop signal), and the full set of codons is called the genetic code.

Explanation:

Hope you have a great day

What process occurs when molecules move from a crowded area to a less crowded area ?


Show/tell me the EVIDENCE

Answers

It’s called diffusion, it’s the random motion of particles from high areas to low areas.

ii) Glucose is absent in urine yet present in glomerular filtrate​

Answers

Answer:

Glucose will be present in blood plasma and glomerular filtrate, but not present in urine (normally) This is because the glucose is selectively reabsorbed in the proximal convoluted tubule. It is reabsorbed from the filtrate into the blood by active transport (symport with Na+ ions)

Explanation:

Glucose will be present in the blood

That is the table pls help

Answers

Abena is the smallest Elephant. Chipo is the largest Elephant. The increase in shoulder height of Bisa over 15 years is 85 cm.

How do elephants develop and grow?

Early in their second decade of life, elephants become sexually mature. African elephants reach sexual maturity between the ages of 10 and 12, while Asian elephants reach sexual maturity around the age of 14.

How much time does it take an elephant to grow up?

Total Size. Physical and emotional development in elephants takes a very long time. The majority of their size is reached by the age of 15, but they frequently continue to gain weight and develop in size until they are around 20 years old.

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4. If the mass of two objects increases and the
distance between them stays the same, what happens to the gravitational force
between the two objects?

A. It decreases.
B. It remains the same.
C. It fluctuates.
D. It increases.

Answers

Answer:

As the mass of either object increases, the force of gravitational attraction between them also increases.

Human activity can contaminate water resources by introducing excess ____, such as nitrogen and phosphorous found in______ and human waste.

Answers

Answer:

minerals and industrial.

Explanation:

Human activity can contaminate water resources by introducing excess minerals such as nitrogen and phosphorous found in industrial and human waste. The agricultural activities such as applying fertilizer and pesticides pollute the water bodies while on the other hand, human waste which is not properly dispose pollute the environment and water bodies that has adverse effect on the environment and its organisms that are present in it.

LIMITED TIME, 20 MINS HELP!!!!! ASAP!!!!
Using electricity sparingly in your home is beneficial for the environment because it:

Select one:

1. increases the amount of greenhouse gases emitted into the
atmosphere.

2. increases the rate of plant growth

3. increases levels of oxygen in the atmosphere.

4. reduces the amount of greenhouse gases emitted into the
atmosphere.

Answers

Answer:

As you improve the energy efficiency of your home, you need less electricity and thus rely less on carbon-intensive power plants. This reduces your home’s demand from the plant, which in turn benefits the environment by reducing their carbon dioxide emissions.

4. reduces the amount of greenhouse gases emitted into the atmosphere.

The Arg genes that encode the enzymes for arginine biosynthesis are located at several positions around the genome of E.coli, and they are regulated coordinately by a transcription regulator encoded by the ArgR gene. The activity of the Arg R protein is modulated by arginine. Upon binding arginine, ArgR alters its conformation, dramatically changing its affinity for the DNA sequences in the promoters of the genes for the arginine biosynthesis. A. Given that ArgR is a repressor protein, would you expect that ArgR would bind more tightly or less tightly to the DNA sequences when arginine is absent?

Answers

Solution :

The Arg genes is used to synthesize the arginine. Arginine is chemical building block. It is very important and is used by our body to make the proteins for our body. When the Arg ID is abundant, the expression for the biosynthetic genes must turned off. And if the ArgR behaves as the gene repressor, then the binding of the arginine increases the infinity for the regulatory sites, and allows it to the bind and then shut off the expression of the genes.

If the ArgR acts as the gene activator, then the binding of the arginine would be predicted to reduce the affinity for the regulatory DNA, and preventing the binding and the shutting off the expression for the Arg genes.

can someone answer this for me please

Answers

Answer:

The constants: 14 hours of light per day; food one time per day 5 oz; wheel for exercise; cage size

The independent variable: the temperature

The dependent variables: length and weight

Data to be collected: weight of mice; length of mice

A flaw in the experiment: the sample size is to small to be random; it doesn't specify a control group

Explanation:

The constants are the controlled variables. The scientist controls these items because a variable that remains unchanged prevents it from having any effect on the outcome.

The independent variable is the condition manipulated by the scientist to see its effects.

The dependent variables are the ones being measured or tested for in an experiment.

Randomization means every subject gets an equal chance at being in the control group. There are to few subjects. A control group would consist of elements that present exactly the same characteristics of the experimental group, except for the variable applied to the latter.

Which of the following science related statements are observations rather than opinions? Select all that apply.

Answers

The most frequent cause of coronary artery disease is the accumulation of fatty plaques in the arteries (atherosclerosis). Poor eating habits, inactivity, obesity, and smoking are risk factors. Choosing a healthy lifestyle can help reduce the risk of atherosclerosis. Thus option C, D is correct.

What are the most common heart disease?

The most prevalent kind of heart disease, coronary heart disease, will claim 382,820 lives in 2020. 20.1 million adults aged 20 and older, or 7.2%, have CAD. Nearly 2 in 10 fatalities from CAD will occur in adults under the age of 65 in 2020.

Therefore, In the US, heart disease is the leading cause of death. Additionally, fewer bees have been visiting my garden lately, indicating that bee populations are declining.

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The given question is incomplete. Complete question is given below:

Which of the following science related statements are observations rather than opinions? Select all that apply.

Whaling should be banned.

Cancer is the worst of all diseases.

Ocean acidity was greater in 2010 than in 2000.

Heart disease is the major cause of death in the United States.

Fewer bees have been in my garden recently, so bee populations must be decreasing.

Discuss the possible theories
around water uptake in plants
Suggest the best and most
acceptable one..
and

Answers

Answer:

There are several theories around water uptake in plants, each with their own strengths and limitations.

One theory is that water is taken up by plants through osmosis, which is the movement of water from a region of high concentration to a region of low concentration. According to this theory, plants absorb water from the soil through their roots, and the water moves across the cell membrane into the plant cells by osmosis. This theory is supported by the fact that plants have a higher concentration of solutes inside their cells than in the soil, which creates a concentration gradient that drives the movement of water into the plant.

Another theory is that water is taken up by plants through transpiration, which is the loss of water vapor from the leaves of plants. According to this theory, plants absorb water through their roots and transport it to the leaves, where it is lost through the stomata (pores) on the surface of the leaves. This theory is supported by the fact that plants can lose significant amounts of water through transpiration, and that the rate of transpiration is influenced by factors such as humidity and temperature.

A third theory is that water is taken up by plants through capillary action, which is the movement of a liquid through a narrow tube or channel. According to this theory, plants absorb water from the soil through their roots and transport it to the rest of the plant through the xylem (water-conducting tissue) by capillary action. This theory is supported by the fact that the xylem of plants has a small diameter and a high surface tension, which allows it to transport water by capillary action.

Overall, the most acceptable theory around water uptake in plants is a combination of osmosis, transpiration, and capillary action. All three mechanisms play a role in the uptake and transport of water in plants, and it is likely that different mechanisms are more or less important depending on the specific plant and the environmental conditions.

Explanation:

definition for artificial language​

Answers

Answer:

An artificial language is a language that has been created by humans, as opposed to a natural language, which is a language that has evolved naturally over time. Artificial languages are typically constructed to be used as a means of communication between humans, although they can also be used for other purposes, such as computer programming.

Explanation:

Anya is a veterinary scientist who works in a lab that is attempting to develop better treatment against snakebites. She is currently setting up an experiment that involves running a current through the venom to see if that will separate the particles inside. In the past, this has not worked, but Anya has high hopes. If you were to read the research paper that Anya writes after the experiment, which would MOST likely be the title?

A.
Exploring Chemicals that Combat Viperine Venom

B.
Results of Shock Therapy on Elapine Venom Samples

C.
Discussing the Quality of Antivenin Serums on the Market

D.
Using Radiation to Dissolve Elapine Venom

Answers

Answer: B

Explanation:

state two types of water​

Answers

Answer:

Mineral water and Distilled water

Why is purification of water and nutrient salts so important in studies involving mineral nutrition using hydroponics?​

Answers

Answer:

Hello!!!

Explanation:

Aish hi hona tum?

Which term best describes the pattern of distribution for the human
population shown in the picture?
O A. Random
B. Sparse
C. Even
D. Clustered

Answers

Answer:

Its B. Sparse

Explanation:

i just took

Population is the number of species in the given area. The image shows sparse pattern of distribution for the humans, i.e., option B.

What is sparse pattern of distribution?

A sparse population is the area where few people resides. In such a case, the area does not densely populated. Their temperatures is colder and have few buildings.

The image here as shown represents sparse pattern of population distribution.

Thus, the correct option is B.

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Q1: what is sleet?

Q2: how big can raindrops get?

Answers

Q1. It is a form of precipitation that consists of ice pellets often mixed with rain or snow. it is usually soft and contains some traces of ice. It can be dangerous to drive with this on the road.

Q2: They can get as big as 4 millimeters. rain drops don't usually get any bigger without seperating into two droplets.

Explanation:

(I hope this helps! Have a great day!)

The disadvantage of batch fermentations, as opposed to continuous feed systems, is that

Select one:
a. new substrate must be added to the fermentor continuously for the fermentation to continue.
b. there is a limit to the amount of product formed since all materials are added to the fermentor at the beginning.
c. it is small scale production of a product.
d. the end product is not as pure as the product made by the continuous feed process.

Answers

Answer:

according to me may be option number b

3. Based on the data, which beak type was more adapted and which was the least adapted?

4. What would happen if all of the birds flew to a new location and the only food available was beans? Which bird would be most successful? Which bird would be least successful?

5. If you come back to this location (question 4) in 50 years, what would you expect to see? (What type of bird will be the most abundant?)

6. Suppose a drought caused the local extinction of beans, pennies, and paperclips. Using your knowledge of the different beak shapes in your community, and understanding of the steps of natural selection, explain how the change in the environment would affect the populations of bird species.

7. List and briefly explain two other characteristics (other than beak shape) that could help a bird survive if this were a "natural" environment.

1.

2.

8. Using at least three complete sentences, explain how this lab simulation provides support for evolution and the Theory of Natural Selection.​

Answers

The bigger beaks types of bird species were more adapted able to eat the larger and harder seeds so more of them survived.

What are types of beak among birds?

Meat-eater, Fruit-and nut-eater, Seed-eater, and Nectar-feeder beaks are seen among birds differentiated based on the nutrition and food consumed.

What three adaptations do birds have?

Beaks (bills), feet, and plumage, in particular, are three physical traits that show distinct environmental adaptations (feathers). The mechanism of evolution that produces living organisms that are adaptable to their circumstances is natural selection.

What technique backs up the hypothesis of evolution?

Evolution is supported by fossil data. Numerous fossils' geographic details show that two species with a shared origin can evolve differently in various environments. An organism can be thought of as an early form from which later forms descended.

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What effect would a series of major volcanic eruptions have on global climate change?

A) the increase in atmospheric particles with increased range globally

B) The blanket effect of Ash would increase temperatures globally

C) atmospheric ash circulation would cause extreme temperature fluctuations and rainfall

D) Ash clouds would reflect the suns energy and decrease temperatures globally

Answers

The effect that a series of major volcanic eruptions would have on global climate change would be Ash clouds would reflect the sun's energy and lower temperatures globally.

What is volcanic winter?

A volcanic winter is the reduction in temperature caused by volcanic ash and sulfuric acid droplets obscuring the sun, usually after a volcanic eruption. Long-term cooling effects are primarily dependent on the ejection of sulfide compounds in aerosol form into the upper atmosphere.

With this information, we can conclude that a major eruption would cause a volcanic winter, with a reduction in temperatures globally.

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